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TOPIC: Multiple sclerosis patients walking, working and skiing after groundbreaking bone marrow stem cells therapy

Could stem cells help people paralysed by MS? 17 May 2014 03:59 #1

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Could stem cells help people paralysed by MS? Scientists reveal they are 'astonished' by landmark study
Mice crippled by version of MS could walk again after less than two weeks
Were previously so disabled they couldn't stand long enough to be fed
Researchers say they had not expected the stem cell treatment to work
These cells may have worked as they were grown in a crowded lab dish

Stem cells could hold the key to treating people paralysed by multiple sclerosis, landmark research has revealed.
Treatment with human stem cells has allowed mice crippled by a version of MS to walk again after less than two weeks.
Scientists admit to being astonished by the result and believe it opens up a new avenue of research in the quest for solutions to MS.
Professor Tom Lane, from the University of Utah, who led the US team, recalled: 'My postdoctoral fellow Dr Lu Chen came to me and said ‘the mice are walking’. I didn’t believe her.'
The genetically engineered mice had a condition that mimics the symptoms of human MS.
They were so disabled they could not stand long enough to eat and drink on their own and had to be hand-fed.
The scientists transplanted human neural stem cells into the animals expecting them to be rejected and provide no benefit.
Instead the experiment yielded spectacular results. Within 10 to 14 days, the mice had regained motor skills and were able to walk again. Six months later, they showed no sign of relapsing.
The findings, published in the journal Stem Cell Reports, suggest the mice experienced at least a partial reversal of their symptoms.
A similar outcome in humans could help patients with potentially disabling progressive stages of the disease for which there are no treatments.

More...
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'This result opens up a whole new area of research for us to figure out why it worked,' said co-author Dr Jeanne Loring, director of the Center for Regenerative Medicine at The Scripps Research Institute in La Jolla, California. 'We’ve long forgotten our original plan.'
MS is an auto-immune condition caused by the body’s own defences attacking myelin, the fatty insulation surrounding nerve fibres.
As myelin is stripped away, nerve impulses can no longer be transmitted properly leading to symptoms ranging from mild tingling to full-blown paralysis.
Drugs that dampen the immune system can slow early forms of the disease, but little can be done for patients in the later stages.
Breakthrough: The scientists transplanted human stem cells into the animals. Within 10 to 14 days, the mice had regained motor skills and were able to walk again.
+2
Breakthrough: The scientists transplanted human stem cells into the animals. Within 10 to 14 days, the mice had regained motor skills and were able to walk again.
Members of the team believe the surprising success may be linked to the way the stem cells were grown in an unusually uncrowded lab dish.
This led to stem cells that were highly potent, with an enhanced ability to produce certain proteins.
Chemical signals from the stem cells instructed each mouse’s own cells to repair the damage caused by MS, said the scientists.
One signal was identified as a protein called TGF-beta, raising the prospect of delivering a similar therapy in the form of a drug.
'Rather than having to engraft stem cells into a patient, which can be challenging from a medical standpoint, we might be able to develop a drug that can be used to deliver the therapy much more easily,' said Prof Lane.
He added: 'We want to try to move as quickly and carefully as possible. I would love to see something that could promote repair and ease the burden that patients with MS have.'




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Could stem cells help people paralysed by MS? 17 May 2014 04:08 #2

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Would be good if it could help those unfortunate souls with MS.

My mother had a family friend born with it, and this female friend was in a wheelchair most of her life, my mother would spend time with her visiting and doing things with her when most others would not.

She sadly passed early too.

A perfectly functioning brain but the body just doesnt play ball, i cant even begin to imagine what that would be like, i get so annoyed if im out of action in a small way over a minor injury.
I remember the good old days, when 90+ year olds in nursing homes lived forever. Darn this pesky virus.

1365 = 1

1.1365 = 1,283,305,580,313,352
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Could stem cells help people paralysed by MS? 17 May 2014 04:19 #3

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novum wrote:

A perfectly functioning brain but the body just doesnt play ball, i cant even begin to imagine what that would be like, i get so annoyed if im out of action in a small way over a minor injury.

f it was not for sports injuries since age 28 i would never have been part of any of these forums TZ, SZ or DIF.

It's hard to be positive and believe in anything when stuff like cancer and MS are stealing peoples chance at life.
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Could stem cells help people paralysed by MS? 17 May 2014 04:48 #4

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.......... wrote:
It's hard to be positive and believe in anything when stuff like cancer and MS are stealing peoples chance at life.

As i said earlier, ive been around MS somewhat and i know it can be a downer even for those around it, let alone those who have it.

I guess we have to make the most of life when we can. Believe in life because you were given it and you still have it.
I remember the good old days, when 90+ year olds in nursing homes lived forever. Darn this pesky virus.

1365 = 1

1.1365 = 1,283,305,580,313,352
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Could stem cells help people paralysed by MS? 17 May 2014 10:03 #5

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The typical upside down, bloody, satanical way of "modern" medicine increasing the amount of stem cells produced naturally in the body is by extracting them from PLACENTA, FOETUSES and UMBILICAL CORDS!


What is transplanting human stem cells into animals good for?

Satanism disguised as "science"!


There are unbloody, uninvasive, natural methods to increase stem cell production but you will never read or hear a thing about them in the msm.


As stem cells are able to transform into any other cell - skin, liver, brain, bone, heart ...... - increasing stem cell production helps cure almost all other diseases/lesions, not only MS.
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Last Edit: 17 May 2014 13:15 by PFIZIPFEI.
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Could stem cells help people paralysed by MS? 17 May 2014 16:05 #6

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Some years ago I attended a StemTech presentation and think their products are good, but not the best, and I don't like multi-level marketing

www.stemenhancefaq.com/

Don't know these products based on colostrum

www.adultstemcells.co.nz/
"The truth must be repeated over and over again,
because error is repeatedly preached among us, not
only by individuals, but by the masses. In periodicals
and cyclopaedias, in schools and universities; every-
where, in fact, error prevails, and is quite easy in the
feeling that it has a decided majority on its side."

~ J. W. v. Goethe

Johannes Lang "The Hollow World Theory" Blog
My Zone by PFIZIPFEI
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Could stem cells help people paralysed by MS? 17 May 2014 19:12 #7

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I am close to family with 2 small boys coping with this -
en.wikipedia.org/wiki/Duchenne_muscular_dystrophy

If it was peace not war that made money and changed society the way they want it - all disease would be a thing of the past - whether genetic splicing is required not not.
Last Edit: 17 May 2014 19:15 by Lizzy.
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Could stem cells help people paralysed by MS? 18 May 2014 04:44 #8

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"Whenever you're in conflict with someone, there is one factor that can make the difference between damaging your relationship and deepening it. That factor is attitude." William James
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Could stem cells help people paralysed by MS? 18 May 2014 18:01 #9

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^Frog that was a real good video you posted.

Her story was very informative.

Makes me think even more about the link between food & inflammation.
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Could stem cells help people paralysed by MS? 18 May 2014 18:55 #10

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Messing about with Stem Cell and Pharmaceutical options before exploring and exhausting natural solutions would seem to be questionable to me.

Glad you found the video useful and it's interesting to note that that talk was banned on TED, who are in partnership with the Bill and Melinda Gates Foundation. :roll:

"Whenever you're in conflict with someone, there is one factor that can make the difference between damaging your relationship and deepening it. That factor is attitude." William James
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Multiple sclerosis patients walking, working and skiing after groundbreaking bone marrow stem cells therapy 10 Jun 2016 06:39 #11

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Multiple sclerosis patients who were severely disabled are walking, working and even downhill skiing again following a breakthrough therapy which completely destroys, then rebuilds, the immune system.

The trial, which is the first in the world to show complete long-term remission from the debilitating disease has been hailed by experts as ‘exciting’ ‘unprecedented,’ and ‘close to curative.’

Although it is unclear what causes MS it is thought that the immune system attacks the protective coating which surrounds nerve cells in the brain and spinal cord leading to inflammation, pain, disability and in severe cases, early death.

The new technique, which is a treatment usually used to fight leukaemia, involves using chemotherapy to entirely eradicate the damaged immune system, before rebooting it with a transfusion of bone marrow cells.

Out of the 24 patients who were given the treatment at least seven years ago, the majority have seen significant improvements . 70 per cent of patients saw a complete stop to the progression of the disease, while 40 per cent saw a reversal in symptoms such as vision loss, muscle weakness and balance loss.

Jennifer, she freaked me out one day when she came to the clinic wearing high heels. This was a girl who could barely walk.
Dr Mark Freedman
Some participants were able to return to work, school, regain the ability to drive, get married and have children.

Trial participant Jennifer Molson, who was diagnosed with MS in 1996, and received her stem cell transplant in 2002 said: “Before my transplant I was unable to walk or work and was living in assisted care.

“Now I am able to walk independently, live in my own home and work full time. I was also able to get married, walk down the aisle with my Dad and dance with my husband.

“I’ve even gone downhill skiing. Thanks to this research I have been given a second chance at life.”

Dr Mark Freedman, of the University of Ottawa and Ottawa Hospital, where the trials were carried out, said: “Jennifer, she freaked me out one day when she came to the clinic wearing high heels. This was a girl who could barely walk.”

MS affects around 100,000 people in Britain. Similar trials have been taking place across the UK and the US but none has shown such long term remission.

The trial included 24 participants with aggressive, relapsing MS who were followed for up to 13 years after treatment.

The procedure involves giving a person medication to coax their stem cells to migrate from their bone marrow into their blood.

These stem cells are then collected from the blood, purified and frozen.

Then, high doses of chemotherapy drugs are used to eliminate the person’s diseased immune system.

The frozen stem cells are then frozen and transplanted back into the same person, so that they can give rise to a new immune system that has no memory of the previous pattern of attacking the central nervous system.
Our trial is the first to show the complete, long-term suppression of all inflammatory activity in people with MS,” said Dr Harold Atkins, a stem cell transplant physician and scientist at The Ottawa Hospital, and associate professor at the University of Ottawa.

“A variation of this procedure has been used to treat leukaemia for decades, but its use for auto-immune diseases is relatively new.

“This is very exciting. However, it is important to note that this therapy can have serious side effects and risks, and would only be appropriate for a small proportion of people with very active MS.”

During the trial one participant died of liver failure due to the treatment and another required intensive care for liver complications.

Dr Emma Gray, Head of Clinical Trials at the MS Society, said: “This type of stem cell transplantation is a rapidly evolving area of MS research that holds a lot of promise for people with certain types of MS.

“This treatment does offer hope, but it’s also an aggressive procedure that comes with substantial risks and requires specialist aftercare. If anyone is considering HSCT we’d recommend they speak to their neurologist.”
But experts said the results constituted a breakthrough in the treatment of MS.

Prof Siddharthan Chandran, MacDonald Professor of Neurology, MRC Centre for Regenerative Medicine, University of Edinburgh, said: “This is an important and carefully conducted proof of concept study that demonstrates that powerful chemotherapy based treatment for a selected subset of MS patients with very aggressive disease is effective in preventing further disabling relapses and, in a proportion, appears to render them effectively disease free.”

Dr Stephen Minger, stem cell biologist and independent consultant, of SLM Blue Skies innovations Ltd said: “The clinical results are truly impressive, in some cases close to being curative.

“For a life-long progressive disease like MS with few treatment options this is really exciting data. I would consider it a breakthrough therapy.”

[/quote

www.telegraph.co.uk/science/2016/06/09/multiple-sclerosis-patients-walking-working-and-skiing-after-gro/
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Multiple sclerosis patients walking, working and skiing after groundbreaking bone marrow stem cells therapy 10 Jun 2016 06:41 #12

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Immunoablation and autologous haemopoietic stem-cell transplantation for aggressive multiple sclerosis: a multicentre single-group phase 2 trial

Summary
Background
Strong immunosuppression, including chemotherapy and immune-depleting antibodies followed by autologous haemopoietic stem-cell transplantation (aHSCT), has been used to treat patients with multiple sclerosis, improving control of relapsing disease. We addressed whether near-complete immunoablation followed by immune cell depleted aHSCT would result in long-term control of multiple sclerosis.

Methods
We did this phase 2 single-arm trial at three hospitals in Canada. We enrolled patients with multiple sclerosis, aged 18–50 years with poor prognosis, ongoing disease activity, and an Expanded Disability Status Scale of 3·0–6·0. Autologous CD34 selected haemopoietic stem-cell grafts were collected after mobilisation with cyclophosphamide and filgrastim. Immunoablation with busulfan, cyclophosphamide, and rabbit anti-thymocyte globulin was followed by aHSCT. The primary outcome was multiple sclerosis activity-free survival (events were clinical relapse, appearance of a new or Gd-enhancing lesion on MRI, and sustained progression of Expanded Disability Status Scale score). This study was registered at ClinicalTrials.gov, NCT01099930.

Findings
Between diagnosis and aHSCT, 24 patients had 167 clinical relapses over 140 patient-years with 188 Gd-enhancing lesions on 48 pre-aHSCT MRI scans. Median follow-up was 6·7 years (range 3·9–12·7). The primary outcome, multiple sclerosis activity-free survival at 3 years after transplantation was 69·6% (95% CI 46·6–84·2). With up to 13 years of follow-up after aHSCT, no relapses occurred and no Gd enhancing lesions or new T2 lesions were seen on 314 MRI sequential scans. The rate of brain atrophy decreased to that expected for healthy controls. One of 24 patients died of transplantation-related complications. 35% of patients had a sustained improvement in their Expanded Disability Status Scale score.

Interpretation
We describe the first treatment to fully halt all detectable CNS inflammatory activity in patients with multiple sclerosis for a prolonged period in the absence of any ongoing disease-modifying drugs. Furthermore, many of the patients had substantial recovery of neurological function despite their disease's aggressive nature.

Funding
Multiple Sclerosis Scientific Research Foundation.

www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)30169-6/abstract
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Multiple sclerosis patients walking, working and skiing after groundbreaking bone marrow stem cells therapy 10 Jun 2016 06:43 #13

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Multiple sclerosis patients walking, working and skiing after groundbreaking bone marrow stem cells therapy 10 Jun 2016 13:09 #14

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I haven't read the full comments, but think about how they extract the stem cells and from what !

It's a huuuge business and it's also connected to Planned Parenthood



The California Superior Court has issued a narrow temporary restraining order preventing the Center for Medical Progress (CMP), a pro-life group, from releasing further undercover video footage taken of three top-level staff of StemExpress.

CMP is the organization behind the series of three videos released over the past three weeks exposing the alleged harvesting and sale of body parts from aborted babies by Planned Parenthood – body parts that are then purchased by StemExpress.
On CNN this morning, Center for Medical Progress leader David Daleiden explained exactly why StemExpress is seeking to block release of secretly recorded video from a meeting he had with its top executives in May:
StemExpress cuts ties with Planned Parenthood after fetal body part scandal
CMP Statement on Alleged “Split” Between Planned Parenthood and StemExpress

Read more on page 2


:right: Planned Parenthood Uses Partial-Birth Abortions to Sell Baby Organs


When I first read the headline of "dots" new thread here I thought it was the usual ad,
only when I noticed that he had started it, I understood that this was meant to be a
regular forum thread.


See also


:right: BBC News: Bahamas: Billionaire claims he is getting younger from Stem Cells
started by "dots" on 28 Feb 2014

:right: Could stem cells help people paralysed by MS?
started by "dots" on 17 May 2014

:right: Scientists smash barrier to growing organs from stem cells
started by TheCatsMeow on 06 Apr 2014

.
"The truth must be repeated over and over again,
because error is repeatedly preached among us, not
only by individuals, but by the masses. In periodicals
and cyclopaedias, in schools and universities; every-
where, in fact, error prevails, and is quite easy in the
feeling that it has a decided majority on its side."

~ J. W. v. Goethe

Johannes Lang "The Hollow World Theory" Blog
My Zone by PFIZIPFEI
Last Edit: 10 Jun 2016 13:20 by PFIZIPFEI.
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Multiple sclerosis patients walking, working and skiing after groundbreaking bone marrow stem cells therapy 11 Jun 2016 21:36 #15

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Pfiz thanks for pointing out that i had already made a similar thread about this i guess Novum should merge them.

Also i don't agree with baby's being used for this type of stuff because that will lead to girls being paid to have abortions.
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